Campbell is employed by NSW Health has received research support from the National Health and Medical Research Council, Australian Food Allergy Foundation, and the Allergy and Immunology Foundation of Australasia and has received travel support from DBV. Umasunthar has received research support from Lincoln Medical. Turner has received research support from the Medical Research Council, NIHR/Imperial BRC, and EU FP7 Programme and has received consultancy fees from UK Food Standards Agency.
Recognition of Commercial Support: This CME has not received external commercial support.ĭisclosure of Relevant Financial Relationships with Commercial Interests: P. To discuss the uncertainties in understanding fatal anaphylaxis. Turner, MD, PhD, Elina Jerschow, MD, Thisanayagam Umasunthar, MD, Robert Lin, MD, Dianne E. List of Design Committee Members: Paul J. Physicians should claim only the credit commensurate with the extent of their participation in the activity. The AAAAI designates this journal-based CME activity for 1.00 AMA PRA Category 1 Credit™. Target Audience: Physicians and researchers within the field of allergic disease.Īccreditation/Provider Statements and Credit Designation: The American Academy of Allergy, Asthma & Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Overall Purpose/Goal: To provide excellent reviews on key aspects of allergic disease to those who research, treat, or manage allergic disease. Credit may be obtained for these courses until August 31, 2018.Ĭopyright Statement: Copyright © 2017-2019. Method of Physician Participation in Learning Process: The core material for these activities can be read in this issue of the Journal or online at the JACI: In Practice Web site: The accompanying tests may only be submitted online at Fax or other copies will not be accepted.ĭate of Original Release: September 1, 2017.
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The rarity of fatal anaphylaxis and the significant quality of life impact of allergic conditions suggest that quality of life impairment should be a key consideration when making treatment decisions in patients at risk for anaphylaxis.Ĭredit can now be obtained, free for a limited time, by reading the review articles in this issue. Upright posture is a feature of fatal anaphylaxis to both food and venom. For fatal venom anaphylaxis, risk factors include middle age, male sex, white race, cardiovascular disease, and possibly mastocytosis insect triggers vary by region. Delayed epinephrine administration is a risk factor common triggers are nuts, seafood, and in children, milk. Fatal food anaphylaxis most commonly occurs during the second and third decades. For fatal drug anaphylaxis, previous cardiovascular morbidity and older age are risk factors, with beta-lactam antibiotics, general anesthetic agents, and radiocontrast injections the commonest triggers. Risk factors for fatal anaphylaxis vary according to cause. Fatal drug anaphylaxis may be increasing, but rates of fatal anaphylaxis to venom and food are stable. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. Up to 5% of the US population has suffered anaphylaxis.
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